California trial protocol reality · checked August 31, 2026
The word “trial” does not tell you what happens inside it.
These 40 records can assign a drug, compare two supports, observe care someone already receives, or watch treatment obtained elsewhere. This page puts those designs next to one another.
Direct-link review preview. Licensed-prescriber and California legal review are pending. This page is not in the public sitemap, carries no review badge and loads no analytics.
The boundary
Sponsor-entered fields, not our verdict.
ClinicalTrials.gov does not review the safety, science or relevance of every listed study. “Randomized,” “quadruple masking” and “placebo comparator” below report what the sponsor entered. They do not prove the design worked, the masking held, the comparison was fair, or the study will help anyone.
This is not an eligibility screen or enrollment route. A listed study can still exclude you, pause locally or change after this snapshot. If you may act on suicidal thoughts, call or text 988, call 911, or go to the nearest emergency department.
One inventory, five cautions
Read the protocol before you read the promise.
Every count comes from the 40 open, coming or invitation-only California records already in the trial desk. Planned enrollment is a target—not the number enrolled, treated or accepted.
How to read the rows
Four fields people routinely collapse into one.
Assignment
Whether the study assigns a drug, assigns only a behavioral component around existing care, or observes treatment.
Arm label
“Placebo,” “active” and “sham” are sponsor-entered arm types. We do not convert them into an efficacy judgment.
Masking
Who the record says is masked. The label does not show whether participants or staff correctly guessed the assignment.
Support
Whether support is typed as a behavioral intervention, named elsewhere in sponsor-entered text, or not named in the fields reviewed.
All 40 records render before JavaScript
Compare the posted design—not the drug’s reputation.
Filters only hide rows already on this page. They stay in this browser tab, are not placed in the URL, are not saved and are not sent anywhere.
40 records shown
Optional three-record view
Choose two or three rows below. Nothing is saved.
NCT05403086Interpretation held
Psilocybin / ketamine
Pragmatic Trial of Psilocybin Therapy in Palliative Care
Protocol comparison only. No California opening, local recruitment status or eligibility is implied.
Why this row is held
Masking is entered as quadruple, while the sponsor masking description calls the trial triple-blind.
The conflicting fields remain visible. We do not choose which sponsor entry is correct.- What the study does
- Study assigns a drug intervention
- Study structure
- Randomized · Parallel
- Masking posted
- QuadrupleParticipant, Care Provider, Investigator, Outcomes Assessor. A masking label is not evidence that masking worked.
- Arms and sponsor types
- 2 arms · Experimental, Active ComparatorRegistry labels an active comparator
- Interventions named
- Psilocybin · KetamineNames only; dose and administration instructions are deliberately omitted.
- Behavior or support
- Support is named in sponsor-entered text, but not typed as a behavioral interventionNo behavioral intervention name to reproduce.
- Planned enrollment
- 100 planned participantsThis is not a count of openings or people currently enrolled.
- Registry update bound to this row
- Nov 25, 2025Design fields checked Aug 31, 2026.
NCT06233344
Psilocybin
Mindfulness-Assisted Psychedelic Therapy
Protocol comparison only. No California opening, local recruitment status or eligibility is implied.
- What the study does
- Study assigns a drug intervention
- Study structure
- Randomized · Parallel
- Masking posted
- NoneNobody posted as masked. A masking label is not evidence that masking worked.
- Arms and sponsor types
- 2 arms · Experimental, Active ComparatorRegistry labels an active comparator
- Interventions named
- Psilocybin plus mindfulness training · PsilocybinNames only; dose and administration instructions are deliberately omitted.
- Behavior or support
- Support is named in sponsor-entered text, but not typed as a behavioral interventionNo behavioral intervention name to reproduce.
- Planned enrollment
- 40 planned participantsThis is not a count of openings or people currently enrolled.
- Registry update bound to this row
- Aug 6, 2026Design fields checked Aug 31, 2026.
NCT06399263
Psilocybin
Study of Psilocybin for Anorexia in Young Adults
Protocol comparison only. No California opening, local recruitment status or eligibility is implied.
- What the study does
- Study assigns a drug intervention
- Study structure
- Not applicable · Single group
- Masking posted
- NoneNobody posted as masked. A masking label is not evidence that masking worked.
- Arms and sponsor types
- 1 arm · ExperimentalOne arm posted
- Interventions named
- Psilocybin · Preparation and Integration SessionsNames only; dose and administration instructions are deliberately omitted.
- Behavior or support
- Behavioral intervention typed in the registryPreparation and Integration Sessions
- Planned enrollment
- 40 planned participantsThis is not a count of openings or people currently enrolled.
- Registry update bound to this row
- Mar 3, 2026Design fields checked Aug 31, 2026.
NCT06455293Interpretation held
Psilocybin
Psilocybin Therapy for Depression in Parkinson's Disease
Protocol comparison only. No California opening, local recruitment status or eligibility is implied.
Why this row is held
The sponsor description mentions placebo or pimavanserin, but the posted arm types are both experimental and do not identify a comparator arm.
The conflicting fields remain visible. We do not choose which sponsor entry is correct.- What the study does
- Study assigns a drug intervention
- Study structure
- Randomized · Parallel
- Masking posted
- QuadrupleParticipant, Care Provider, Investigator, Outcomes Assessor. A masking label is not evidence that masking worked.
- Arms and sponsor types
- 2 arms · ExperimentalSeveral arms; no comparator arm type posted
- Interventions named
- Psilocybin · PimavanserinNames only; dose and administration instructions are deliberately omitted.
- Behavior or support
- Support is named in sponsor-entered text, but not typed as a behavioral interventionNo behavioral intervention name to reproduce.
- Planned enrollment
- 60 planned participantsThis is not a count of openings or people currently enrolled.
- Registry update bound to this row
- Aug 7, 2026Design fields checked Aug 31, 2026.
NCT06793397
CYB003 (psilocin analog)
A Study of a Deuterated Psilocin Analog in Major Depressive Disorder
Protocol comparison only. No California opening, local recruitment status or eligibility is implied.
- What the study does
- Study assigns a drug intervention
- Study structure
- Randomized · Parallel
- Masking posted
- QuadrupleParticipant, Care Provider, Investigator, Outcomes Assessor. A masking label is not evidence that masking worked.
- Arms and sponsor types
- 3 arms · Experimental, Placebo ComparatorRegistry labels a placebo comparator
- Interventions named
- CYB003 · Psychological SupportNames only; dose and administration instructions are deliberately omitted.
- Behavior or support
- Behavioral intervention typed in the registryPsychological Support
- Planned enrollment
- 330 planned participantsThis is not a count of openings or people currently enrolled.
- Registry update bound to this row
- Sep 25, 2026Design fields checked Aug 31, 2026.
NCT06814522
Psilocybin
Psilocybin-Assisted Therapy for Physician Well-Being and Burnout
Protocol comparison only. No California opening, local recruitment status or eligibility is implied.
- What the study does
- Study assigns a drug intervention
- Study structure
- Not applicable · Single group
- Masking posted
- NoneNobody posted as masked. A masking label is not evidence that masking worked.
- Arms and sponsor types
- 1 arm · ExperimentalOne arm posted
- Interventions named
- PsilocybinNames only; dose and administration instructions are deliberately omitted.
- Behavior or support
- Support is named in sponsor-entered text, but not typed as a behavioral interventionNo behavioral intervention name to reproduce.
- Planned enrollment
- 10 planned participantsThis is not a count of openings or people currently enrolled.
- Registry update bound to this row
- Jul 21, 2026Design fields checked Aug 31, 2026.
NCT07281352
Psilocybin
Psilocybin-Assisted CBT for Depression
Protocol comparison only. No California opening, local recruitment status or eligibility is implied.
- What the study does
- Study assigns a drug intervention
- Study structure
- Randomized · Parallel
- Masking posted
- SingleOutcomes Assessor. A masking label is not evidence that masking worked.
- Arms and sponsor types
- 2 arms · Experimental, Active ComparatorRegistry labels an active comparator · Several behavioral interventions named
- Interventions named
- Psilocybin · cognitive behavioral therapy · Minimal supportive therapyNames only; dose and administration instructions are deliberately omitted.
- Behavior or support
- Behavioral intervention typed in the registrycognitive behavioral therapy · Minimal supportive therapy
- Planned enrollment
- 50 planned participantsThis is not a count of openings or people currently enrolled.
- Registry update bound to this row
- Feb 12, 2026Design fields checked Aug 31, 2026.
NCT07479550Interpretation held
Psilocybin
Study of Psilocybin Under Anesthesia Controlled by EEG
Protocol comparison only. No California opening, local recruitment status or eligibility is implied.
Why this row is held
The sponsor intervention-model text says four dosing conditions but names placebo and two psilocybin conditions; the summary says four sessions.
The conflicting fields remain visible. We do not choose which sponsor entry is correct.- What the study does
- Study assigns a drug intervention
- Study structure
- Randomized · Crossover
- Masking posted
- DoubleParticipant, Outcomes Assessor. A masking label is not evidence that masking worked.
- Arms and sponsor types
- 2 arms · ExperimentalSeveral arms; no comparator arm type posted
- Interventions named
- Psilocybin · Propofol · PlaceboNames only; dose and administration instructions are deliberately omitted.
- Behavior or support
- No support component named in the registry fields reviewedNo behavioral intervention name to reproduce.
- Planned enrollment
- 10 planned participantsThis is not a count of openings or people currently enrolled.
- Registry update bound to this row
- May 6, 2026Design fields checked Aug 31, 2026.
NCT07566104
Psilocybin
Group Psilocybin-Assisted CBT for Depression
Protocol comparison only. No California opening, local recruitment status or eligibility is implied.
- What the study does
- Study assigns a drug intervention
- Study structure
- Not applicable · Single group
- Masking posted
- NoneNobody posted as masked. A masking label is not evidence that masking worked.
- Arms and sponsor types
- 1 arm · ExperimentalOne arm posted
- Interventions named
- Psilocybin · Group Cognitive Behavioral TherapyNames only; dose and administration instructions are deliberately omitted.
- Behavior or support
- Behavioral intervention typed in the registryGroup Cognitive Behavioral Therapy
- Planned enrollment
- 30 planned participantsThis is not a count of openings or people currently enrolled.
- Registry update bound to this row
- May 4, 2026Design fields checked Aug 31, 2026.
NCT07756736
Psilocybin
Psilocybin Therapy for Methamphetamine Use Disorder and HIV
Protocol comparison only. No California opening, local recruitment status or eligibility is implied.
- What the study does
- Study assigns a drug intervention
- Study structure
- Randomized · Parallel
- Masking posted
- QuadrupleParticipant, Care Provider, Investigator, Outcomes Assessor. A masking label is not evidence that masking worked.
- Arms and sponsor types
- 2 arms · Experimental, Active ComparatorRegistry labels an active comparator
- Interventions named
- Psilocybin · Motivational SupportNames only; dose and administration instructions are deliberately omitted.
- Behavior or support
- Behavioral intervention typed in the registryMotivational Support
- Planned enrollment
- 30 planned participantsThis is not a count of openings or people currently enrolled.
- Registry update bound to this row
- Aug 11, 2026Design fields checked Aug 31, 2026.
NCT07592689
LSD / lysergide (DT120, formerly MM120)
A Phase 3 Trial of DT120 for Major Depressive Disorder
Protocol comparison only. No California opening, local recruitment status or eligibility is implied.
- What the study does
- Study assigns a drug intervention
- Study structure
- Randomized · Parallel
- Masking posted
- TripleParticipant, Investigator, Outcomes Assessor. A masking label is not evidence that masking worked.
- Arms and sponsor types
- 3 arms · Placebo Comparator, Sham Comparator, ExperimentalRegistry labels a placebo comparator · Registry labels a sham comparator
- Interventions named
- Placebo · DT120Names only; dose and administration instructions are deliberately omitted.
- Behavior or support
- No support component named in the registry fields reviewedNo behavioral intervention name to reproduce.
- Planned enrollment
- 165 planned participantsThis is not a count of openings or people currently enrolled.
- Registry update bound to this row
- Aug 10, 2026Design fields checked Aug 31, 2026.
NCT05770375
MDMA
Tolerability of MDMA in Schizophrenia
Protocol comparison only. No California opening, local recruitment status or eligibility is implied.
- What the study does
- Study assigns a drug intervention
- Study structure
- Not applicable · Single group
- Masking posted
- NoneNobody posted as masked. A masking label is not evidence that masking worked.
- Arms and sponsor types
- 1 arm · ExperimentalOne arm posted
- Interventions named
- MDMANames only; dose and administration instructions are deliberately omitted.
- Behavior or support
- No support component named in the registry fields reviewedNo behavioral intervention name to reproduce.
- Planned enrollment
- 20 planned participantsThis is not a count of openings or people currently enrolled.
- Registry update bound to this row
- Jul 17, 2026Design fields checked Aug 31, 2026.
NCT05783817
MDMA
MDMA-Assisted CBT for OCD
Protocol comparison only. No California opening, local recruitment status or eligibility is implied.
- What the study does
- Study assigns a drug intervention
- Study structure
- Randomized · Parallel
- Masking posted
- QuadrupleParticipant, Care Provider, Investigator, Outcomes Assessor. A masking label is not evidence that masking worked.
- Arms and sponsor types
- 2 arms · Experimental, Active ComparatorRegistry labels an active comparator
- Interventions named
- MDMA · Methamphetamine · Cognitive Behavioral Therapy (CBT)Names only; dose and administration instructions are deliberately omitted.
- Behavior or support
- Behavioral intervention typed in the registryCognitive Behavioral Therapy (CBT)
- Planned enrollment
- 40 planned participantsThis is not a count of openings or people currently enrolled.
- Registry update bound to this row
- Mar 5, 2026Design fields checked Aug 31, 2026.
NCT05790239
MDMA
MDMA-Assisted Therapy for Veterans With PTSD
Protocol comparison only. No California opening, local recruitment status or eligibility is implied.
- What the study does
- Study assigns a drug intervention
- Study structure
- Randomized · Parallel
- Masking posted
- TripleParticipant, Care Provider, Investigator. A masking label is not evidence that masking worked.
- Arms and sponsor types
- 2 arms · Experimental, Active ComparatorRegistry labels an active comparator
- Interventions named
- MDMA · d-amphetamine · TherapyNames only; dose and administration instructions are deliberately omitted.
- Behavior or support
- Behavioral intervention typed in the registryTherapy
- Planned enrollment
- 40 planned participantsThis is not a count of openings or people currently enrolled.
- Registry update bound to this row
- Aug 19, 2026Design fields checked Aug 31, 2026.
NCT05837845
MDMA
MDMA-Assisted Cognitive Processing Therapy for Veterans With PTSD
Protocol comparison only. No California opening, local recruitment status or eligibility is implied.
- What the study does
- Study assigns a drug intervention
- Study structure
- Randomized · Parallel
- Masking posted
- SingleOutcomes Assessor. A masking label is not evidence that masking worked.
- Arms and sponsor types
- 2 arms · ExperimentalSeveral arms; no comparator arm type posted · Several behavioral interventions named
- Interventions named
- MDMA · Cognitive Processing Therapy · MDMA-assisted Cognitive Processing Therapy (MDMA-aCPT)Names only; dose and administration instructions are deliberately omitted.
- Behavior or support
- Behavioral intervention typed in the registryCognitive Processing Therapy · MDMA-assisted Cognitive Processing Therapy (MDMA-aCPT)
- Planned enrollment
- 30 planned participantsThis is not a count of openings or people currently enrolled.
- Registry update bound to this row
- Jul 31, 2025Design fields checked Aug 31, 2026.
NCT07456696
Methylone (TSND-201)
Safety and Efficacy of TSND-201 for PTSD
Protocol comparison only. No California opening, local recruitment status or eligibility is implied.
- What the study does
- Study assigns a drug intervention
- Study structure
- Randomized · Parallel
- Masking posted
- QuadrupleParticipant, Care Provider, Investigator, Outcomes Assessor. A masking label is not evidence that masking worked.
- Arms and sponsor types
- 3 arms · Experimental, Placebo ComparatorRegistry labels a placebo comparator
- Interventions named
- TSND-201 · PlaceboNames only; dose and administration instructions are deliberately omitted.
- Behavior or support
- No support component named in the registry fields reviewedNo behavioral intervention name to reproduce.
- Planned enrollment
- 300 planned participantsThis is not a count of openings or people currently enrolled.
- Registry update bound to this row
- Sep 17, 2026Design fields checked Aug 31, 2026.
NCT05940324
Ketamine
Ketamine's Rapid Effects in OCD
Protocol comparison only. No California opening, local recruitment status or eligibility is implied.
- What the study does
- Study assigns a drug intervention
- Study structure
- Randomized · Parallel
- Masking posted
- QuadrupleParticipant, Care Provider, Investigator, Outcomes Assessor. A masking label is not evidence that masking worked.
- Arms and sponsor types
- 3 arms · Experimental, Placebo Comparator, No InterventionRegistry labels a placebo comparator · Registry labels a no-intervention arm
- Interventions named
- Ketamine · Naltrexone Pill · Placebo pillNames only; dose and administration instructions are deliberately omitted.
- Behavior or support
- No support component named in the registry fields reviewedNo behavioral intervention name to reproduce.
- Planned enrollment
- 150 planned participantsThis is not a count of openings or people currently enrolled.
- Registry update bound to this row
- Apr 24, 2026Design fields checked Aug 31, 2026.
NCT06575075
Hydroxynorketamine (RR-HNK)
Pilot Study of RR-HNK in OCD
Protocol comparison only. No California opening, local recruitment status or eligibility is implied.
- What the study does
- Study assigns a drug intervention
- Study structure
- Randomized · Parallel
- Masking posted
- TripleParticipant, Care Provider, Investigator. A masking label is not evidence that masking worked.
- Arms and sponsor types
- 3 arms · Experimental, Placebo ComparatorRegistry labels a placebo comparator
- Interventions named
- RR-HNK/Hydroxynorketamine · PlaceboNames only; dose and administration instructions are deliberately omitted.
- Behavior or support
- No support component named in the registry fields reviewedNo behavioral intervention name to reproduce.
- Planned enrollment
- 45 planned participantsThis is not a count of openings or people currently enrolled.
- Registry update bound to this row
- Aug 12, 2026Design fields checked Aug 31, 2026.
NCT07369089
Ketamine
Ketamine-Assisted Mindfulness-Oriented Recovery for Opioid Use Disorder
Protocol comparison only. No California opening, local recruitment status or eligibility is implied.
- What the study does
- Study assigns a drug intervention
- Study structure
- Randomized · Parallel
- Masking posted
- DoubleInvestigator, Outcomes Assessor. A masking label is not evidence that masking worked.
- Arms and sponsor types
- 2 arms · Experimental, Active ComparatorRegistry labels an active comparator · Several behavioral interventions named
- Interventions named
- Ketamine · Mindfulness-Oriented Recovery Enhancement (MORE) · Support GroupNames only; dose and administration instructions are deliberately omitted.
- Behavior or support
- Behavioral intervention typed in the registryMindfulness-Oriented Recovery Enhancement (MORE) · Support Group
- Planned enrollment
- 88 planned participantsThis is not a count of openings or people currently enrolled.
- Registry update bound to this row
- Feb 3, 2026Design fields checked Aug 31, 2026.
NCT07396220
Esketamine
Psychotherapy With Intranasal Esketamine for Suicidal Ideation
Protocol comparison only. No California opening, local recruitment status or eligibility is implied.
- What the study does
- Existing care; study assigns a behavioral component
- Study structure
- Randomized · Parallel
- Masking posted
- NoneNobody posted as masked. A masking label is not evidence that masking worked.
- Arms and sponsor types
- 2 arms · Active Comparator, ExperimentalRegistry labels an active comparator
- Interventions named
- Naturalistic Intranasal Esketamine · Brief Cognitive Behavioral Therapy for Suicide PreventionNames only; dose and administration instructions are deliberately omitted.
- Behavior or support
- Behavioral intervention typed in the registryBrief Cognitive Behavioral Therapy for Suicide Prevention
- Planned enrollment
- 56 planned participantsThis is not a count of openings or people currently enrolled.
- Registry update bound to this row
- Feb 9, 2026Design fields checked Aug 31, 2026.
NCT06034821
Ketamine
ECT Versus Ketamine Over the Lifespan
Protocol comparison only. No California opening, local recruitment status or eligibility is implied.
- What the study does
- Study assigns a drug intervention
- Study structure
- Randomized · Parallel
- Masking posted
- NoneNobody posted as masked. A masking label is not evidence that masking worked.
- Arms and sponsor types
- 2 arms · Active ComparatorRegistry labels an active comparator
- Interventions named
- Subanesthetic dose intravenous ketamine (KET) · Electroconvulsive therapy (ECT)Names only; dose and administration instructions are deliberately omitted.
- Behavior or support
- No support component named in the registry fields reviewedNo behavioral intervention name to reproduce.
- Planned enrollment
- 1,500 planned participantsThis is not a count of openings or people currently enrolled.
- Registry update bound to this row
- Dec 15, 2025Design fields checked Aug 31, 2026.
NCT07716098Interpretation held
Esketamine
Esketamine Nasal Spray Versus Placebo in Treatment-Resistant Depression
Protocol comparison only. No California opening, local recruitment status or eligibility is implied.
Why this row is held
The placebo arm is linked to both esketamine intervention names as well as placebo in the sponsor-entered arm mapping.
The conflicting fields remain visible. We do not choose which sponsor entry is correct.- What the study does
- Study assigns a drug intervention
- Study structure
- Randomized · Parallel
- Masking posted
- DoubleParticipant, Investigator. A masking label is not evidence that masking worked.
- Arms and sponsor types
- 3 arms · Experimental, Placebo ComparatorRegistry labels a placebo comparator
- Interventions named
- Esketamine · PlaceboNames only; dose and administration instructions are deliberately omitted.
- Behavior or support
- No support component named in the registry fields reviewedNo behavioral intervention name to reproduce.
- Planned enrollment
- 348 planned participantsThis is not a count of openings or people currently enrolled.
- Registry update bound to this row
- Sep 25, 2026Design fields checked Aug 31, 2026.
NCT07693257
DMT
Neural Effects of Intravenous DMT
Protocol comparison only. No California opening, local recruitment status or eligibility is implied.
- What the study does
- Study assigns a drug intervention
- Study structure
- Randomized · Crossover
- Masking posted
- DoubleParticipant, Investigator. A masking label is not evidence that masking worked.
- Arms and sponsor types
- 2 arms · ExperimentalSeveral arms; no comparator arm type posted
- Interventions named
- N,N-Dimethyltryptamine (DMT)Names only; dose and administration instructions are deliberately omitted.
- Behavior or support
- No support component named in the registry fields reviewedNo behavioral intervention name to reproduce.
- Planned enrollment
- 20 planned participantsThis is not a count of openings or people currently enrolled.
- Registry update bound to this row
- Jul 9, 2026Design fields checked Aug 31, 2026.
NCT07226570
Ibogaine
Mapping Ibogaine Neural Dynamics in Opioid Use Disorder
Protocol comparison only. No California opening, local recruitment status or eligibility is implied.
- What the study does
- Study observes treatment obtained outside the U.S.
- Study structure
- Observational
- Masking posted
- Not applicableMasking does not apply to this observational record.
- Arms and sponsor types
- 1 arm · No interventional arm typeObservational groups
- Interventions named
- Observational study with MRI/EEGNames only; dose and administration instructions are deliberately omitted.
- Behavior or support
- Not applicable to this observational recordNo behavioral intervention name to reproduce.
- Planned enrollment
- 20 planned participantsThis is not a count of openings or people currently enrolled.
- Registry update bound to this row
- May 18, 2026Design fields checked Aug 31, 2026.
NCT05265546
Psilocybin
Effects of Psilocybin on Visual Perception and Brain Representations
Protocol comparison only. No California opening, local recruitment status or eligibility is implied.
- What the study does
- Study assigns a drug intervention
- Study structure
- Randomized · Crossover
- Masking posted
- DoubleParticipant, Investigator. A masking label is not evidence that masking worked.
- Arms and sponsor types
- 2 arms · Experimental, OtherSeveral arms; no comparator arm type posted
- Interventions named
- PsilocybinNames only; dose and administration instructions are deliberately omitted.
- Behavior or support
- No support component named in the registry fields reviewedNo behavioral intervention name to reproduce.
- Planned enrollment
- 80 planned participantsThis is not a count of openings or people currently enrolled.
- Registry update bound to this row
- Jul 10, 2026Design fields checked Aug 31, 2026.
NCT06367738Interpretation held
Psilocybin
Persisting Effects of Psilocybin on Structural Plasticity in Older Adults
Protocol comparison only. No California opening, local recruitment status or eligibility is implied.
Why this row is held
The sponsor record combines randomized allocation and three arm groups with a single-group intervention model.
The conflicting fields remain visible. We do not choose which sponsor entry is correct.- What the study does
- Study assigns a drug intervention
- Study structure
- Randomized · Single group
- Masking posted
- TripleParticipant, Care Provider, Investigator. A masking label is not evidence that masking worked.
- Arms and sponsor types
- 3 arms · ExperimentalSeveral arms; no comparator arm type posted
- Interventions named
- PsilocybinNames only; dose and administration instructions are deliberately omitted.
- Behavior or support
- No support component named in the registry fields reviewedNo behavioral intervention name to reproduce.
- Planned enrollment
- 40 planned participantsThis is not a count of openings or people currently enrolled.
- Registry update bound to this row
- Oct 21, 2025Design fields checked Aug 31, 2026.
NCT06626139
Psilocybin
Interaction of Psilocybin and the Context of Administration
Protocol comparison only. No California opening, local recruitment status or eligibility is implied.
- What the study does
- Study assigns a drug intervention
- Study structure
- Randomized · Factorial
- Masking posted
- DoubleParticipant, Investigator. A masking label is not evidence that masking worked.
- Arms and sponsor types
- 4 arms · Experimental, Placebo ComparatorRegistry labels a placebo comparator · Several behavioral interventions named
- Interventions named
- Psilocybin · Context 1 · Context 2 · PlaceboNames only; dose and administration instructions are deliberately omitted.
- Behavior or support
- Behavioral intervention typed in the registryContext 1 · Context 2
- Planned enrollment
- 120 planned participantsThis is not a count of openings or people currently enrolled.
- Registry update bound to this row
- Jun 4, 2026Design fields checked Aug 31, 2026.
NCT06919640
Psilocybin
Psilocybin With Intracranial Neural Sensing
Protocol comparison only. No California opening, local recruitment status or eligibility is implied.
- What the study does
- Study assigns a drug intervention
- Study structure
- Not applicable · Single group
- Masking posted
- NoneNobody posted as masked. A masking label is not evidence that masking worked.
- Arms and sponsor types
- 1 arm · ExperimentalOne arm posted
- Interventions named
- PsilocybinNames only; dose and administration instructions are deliberately omitted.
- Behavior or support
- No support component named in the registry fields reviewedNo behavioral intervention name to reproduce.
- Planned enrollment
- 20 planned participantsThis is not a count of openings or people currently enrolled.
- Registry update bound to this row
- Jun 6, 2025Design fields checked Aug 31, 2026.
NCT07386730
Psilocybin
Psychedelics in Healthy Older Adults With Low Well-Being
Protocol comparison only. No California opening, local recruitment status or eligibility is implied.
- What the study does
- Study assigns a drug intervention
- Study structure
- Randomized · Parallel
- Masking posted
- TripleParticipant, Care Provider, Outcomes Assessor. A masking label is not evidence that masking worked.
- Arms and sponsor types
- 4 arms · ExperimentalSeveral arms; no comparator arm type posted
- Interventions named
- Psilocybin · Dextromethorphan (DXM)Names only; dose and administration instructions are deliberately omitted.
- Behavior or support
- No support component named in the registry fields reviewedNo behavioral intervention name to reproduce.
- Planned enrollment
- 80 planned participantsThis is not a count of openings or people currently enrolled.
- Registry update bound to this row
- Jun 8, 2026Design fields checked Aug 31, 2026.
NCT07516405
Psilocybin
Safety and Tolerability of Psilocybin in Healthy Older Adults
Protocol comparison only. No California opening, local recruitment status or eligibility is implied.
- What the study does
- Study assigns a drug intervention
- Study structure
- Not applicable · Single group
- Masking posted
- NoneNobody posted as masked. A masking label is not evidence that masking worked.
- Arms and sponsor types
- 1 arm · ExperimentalOne arm posted
- Interventions named
- PsilocybinNames only; dose and administration instructions are deliberately omitted.
- Behavior or support
- No support component named in the registry fields reviewedNo behavioral intervention name to reproduce.
- Planned enrollment
- 40 planned participantsThis is not a count of openings or people currently enrolled.
- Registry update bound to this row
- Aug 10, 2026Design fields checked Aug 31, 2026.
NCT07002034
RE104
RE104 for Adjustment Disorder With Cancer or Other Medical Illness
Protocol comparison only. No California opening, local recruitment status or eligibility is implied.
- What the study does
- Study assigns a drug intervention
- Study structure
- Randomized · Parallel
- Masking posted
- TripleParticipant, Investigator, Outcomes Assessor. A masking label is not evidence that masking worked.
- Arms and sponsor types
- 2 arms · Active Comparator, ExperimentalRegistry labels an active comparator
- Interventions named
- RE104 for InjectionNames only; dose and administration instructions are deliberately omitted.
- Behavior or support
- No support component named in the registry fields reviewedNo behavioral intervention name to reproduce.
- Planned enrollment
- 100 planned participantsThis is not a count of openings or people currently enrolled.
- Registry update bound to this row
- Aug 24, 2026Design fields checked Aug 31, 2026.
NCT07489651
RE104
RE104 for Generalized Anxiety Disorder
Protocol comparison only. No California opening, local recruitment status or eligibility is implied.
- What the study does
- Study assigns a drug intervention
- Study structure
- Randomized · Parallel
- Masking posted
- TripleParticipant, Investigator, Outcomes Assessor. A masking label is not evidence that masking worked.
- Arms and sponsor types
- 2 arms · Placebo Comparator, ExperimentalRegistry labels a placebo comparator
- Interventions named
- RE104 for Injection · PlaceboNames only; dose and administration instructions are deliberately omitted.
- Behavior or support
- No support component named in the registry fields reviewedNo behavioral intervention name to reproduce.
- Planned enrollment
- 64 planned participantsThis is not a count of openings or people currently enrolled.
- Registry update bound to this row
- Aug 18, 2026Design fields checked Aug 31, 2026.
NCT06736769
Ketamine
Ketamine Effects on Learning in Eating Disorders
Protocol comparison only. No California opening, local recruitment status or eligibility is implied.
- What the study does
- Study assigns a drug intervention
- Study structure
- Not applicable · Single group
- Masking posted
- NoneNobody posted as masked. A masking label is not evidence that masking worked.
- Arms and sponsor types
- 1 arm · ExperimentalOne arm posted
- Interventions named
- Ketamine infusionNames only; dose and administration instructions are deliberately omitted.
- Behavior or support
- No support component named in the registry fields reviewedNo behavioral intervention name to reproduce.
- Planned enrollment
- 20 planned participantsThis is not a count of openings or people currently enrolled.
- Registry update bound to this row
- Jun 12, 2026Design fields checked Aug 31, 2026.
NCT05962424
Ketamine
Human Neural Circuits Electrophysiology During Cognition
Protocol comparison only. No California opening, local recruitment status or eligibility is implied.
- What the study does
- Study assigns a drug intervention
- Study structure
- Not applicable · Single group
- Masking posted
- NoneNobody posted as masked. A masking label is not evidence that masking worked.
- Arms and sponsor types
- 1 arm · ExperimentalOne arm posted
- Interventions named
- Ketamine HydrochlorideNames only; dose and administration instructions are deliberately omitted.
- Behavior or support
- No support component named in the registry fields reviewedNo behavioral intervention name to reproduce.
- Planned enrollment
- 120 planned participantsThis is not a count of openings or people currently enrolled.
- Registry update bound to this row
- Apr 22, 2026Design fields checked Aug 31, 2026.
NCT04861051
Ketamine
Understanding Ketamine's Dissociative Effects
Protocol comparison only. No California opening, local recruitment status or eligibility is implied.
- What the study does
- Study assigns a drug intervention
- Study structure
- Not applicable · Single group
- Masking posted
- NoneNobody posted as masked. A masking label is not evidence that masking worked.
- Arms and sponsor types
- 1 arm · OtherOne arm posted
- Interventions named
- KetamineNames only; dose and administration instructions are deliberately omitted.
- Behavior or support
- No support component named in the registry fields reviewedNo behavioral intervention name to reproduce.
- Planned enrollment
- 20 planned participantsThis is not a count of openings or people currently enrolled.
- Registry update bound to this row
- Apr 22, 2026Design fields checked Aug 31, 2026.
NCT06605105
CYB003 (psilocin analog)
CYB003 Long-Term Extension Study in Major Depressive Disorder
Protocol comparison only. No California opening, local recruitment status or eligibility is implied.
- What the study does
- Study assigns a drug intervention
- Study structure
- Not applicable · Single group
- Masking posted
- NoneNobody posted as masked. A masking label is not evidence that masking worked.
- Arms and sponsor types
- 1 arm · ExperimentalOne arm posted
- Interventions named
- CYB003Names only; dose and administration instructions are deliberately omitted.
- Behavior or support
- Support is named in sponsor-entered text, but not typed as a behavioral interventionNo behavioral intervention name to reproduce.
- Planned enrollment
- 468 planned participantsThis is not a count of openings or people currently enrolled.
- Registry update bound to this row
- Sep 25, 2026Design fields checked Aug 31, 2026.
NCT07528014
Esketamine
Longitudinal Assessment of Depression Treatment Response
Protocol comparison only. No California opening, local recruitment status or eligibility is implied.
- What the study does
- Study observes existing care
- Study structure
- Observational
- Masking posted
- Not applicableMasking does not apply to this observational record.
- Arms and sponsor types
- 3 arms · No interventional arm typeObservational groups
- Interventions named
- No intervention name postedNames only; dose and administration instructions are deliberately omitted.
- Behavior or support
- Not applicable to this observational recordNo behavioral intervention name to reproduce.
- Planned enrollment
- 5,000 planned participantsThis is not a count of openings or people currently enrolled.
- Registry update bound to this row
- Apr 14, 2026Design fields checked Aug 31, 2026.
NCT06823024
Esketamine
Speech Markers of Response to Spravato or TMS
Protocol comparison only. No California opening, local recruitment status or eligibility is implied.
- What the study does
- Study observes existing care
- Study structure
- Observational
- Masking posted
- Not applicableMasking does not apply to this observational record.
- Arms and sponsor types
- 2 arms · No interventional arm typeObservational groups
- Interventions named
- No intervention name postedNames only; dose and administration instructions are deliberately omitted.
- Behavior or support
- Not applicable to this observational recordNo behavioral intervention name to reproduce.
- Planned enrollment
- 200 planned participantsThis is not a count of openings or people currently enrolled.
- Registry update bound to this row
- Mar 18, 2025Design fields checked Aug 31, 2026.
NCT06526078
Ketamine / esketamine
Cognitive Training as an Adjunct to Ketamine in Real-World Clinics
Protocol comparison only. No California opening, local recruitment status or eligibility is implied.
- What the study does
- Existing care; study assigns a behavioral component
- Study structure
- Randomized · Parallel
- Masking posted
- QuadrupleParticipant, Care Provider, Investigator, Outcomes Assessor. A masking label is not evidence that masking worked.
- Arms and sponsor types
- 2 arms · Experimental, Sham ComparatorRegistry labels a sham comparator · Several behavioral interventions named
- Interventions named
- Cognitive Training · Sham TrainingNames only; dose and administration instructions are deliberately omitted.
- Behavior or support
- Behavioral intervention typed in the registryCognitive Training · Sham Training
- Planned enrollment
- 600 planned participantsThis is not a count of openings or people currently enrolled.
- Registry update bound to this row
- Aug 19, 2026Design fields checked Aug 31, 2026.
NCT06231563Interpretation held
Ketamine
Ketamine for Depression in Veterans With Parkinson's Disease
Protocol comparison only. No California opening, local recruitment status or eligibility is implied.
Why this row is held
The masking field says triple and names Participant, Investigator and Outcomes Assessor, while the sponsor masking description says double-masked.
The conflicting fields remain visible. We do not choose which sponsor entry is correct.- What the study does
- Study assigns a drug intervention
- Study structure
- Randomized · Parallel
- Masking posted
- TripleParticipant, Investigator, Outcomes Assessor. A masking label is not evidence that masking worked.
- Arms and sponsor types
- 2 arms · Experimental, Placebo ComparatorRegistry labels a placebo comparator
- Interventions named
- Ketamine · RemimazolamNames only; dose and administration instructions are deliberately omitted.
- Behavior or support
- No support component named in the registry fields reviewedNo behavioral intervention name to reproduce.
- Planned enrollment
- 80 planned participantsThis is not a count of openings or people currently enrolled.
- Registry update bound to this row
- Apr 13, 2026Design fields checked Aug 31, 2026.
No row matches all six filters.
Clear one field. An empty view is not evidence that no study exists or that no one can receive care.
Every row returns to the federal record.
- ClinicalTrials.gov, Study Data Structure and the API v2 record pattern. All 40 record IDs and their posted update dates were checked August 31, 2026.
- ClinicalTrials.gov, How to Read a Study Record: identification, status, sponsor-entered study design, arms, interventions and enrollment fields.
- ClinicalTrials.gov, Disclaimer: listing does not mean the U.S. government evaluated a study's safety or science.
- U.S. Food and Drug Administration, Psychedelic Drugs: Considerations for Clinical Investigations, final guidance, July 2026.
- Blinding Integrity in Psychedelic Randomized Clinical Trials: A Systematic Review, JAMA Psychiatry, 2026.
- Federal informed-consent requirements: 21 CFR §50.25 and 45 CFR §46.116.
Educational information, not medical advice, legal advice, research recruitment, an eligibility finding, a provider judgment or a recommendation to enroll. Sponsor-entered fields are shown as entered or mechanically grouped. Six conflicting or incomplete field combinations are held rather than resolved. Next full human review is due September 30, 2026. Licensed-prescriber and California legal review pending. Paid for by participating therapists. Inclusion is computed, never purchased. No ads. No data sold.