A study is a question, not a treatment promise.
This desk names the drug, condition, phase, California city and exact federal record. It also tells you when a study is observational, invitation-only or not a treatment study at all.
Registry records checked August 28, 2026. Status can change between checks. Licensed-prescriber and California legal review are pending; no review badge is claimed.
“Recruiting” describes the record. It does not say you qualify.
ClinicalTrials.gov is a registry, not a booking service and not FDA approval. A sponsor enters the record. A local site may be recruiting while another site in the same study is not. The study team—not this site—decides eligibility after screening.
A trial contact is never a crisis service. If you may act on suicidal thoughts, call or text 988, call 911, or go to the nearest emergency department.
40 California records, sorted by what they actually do.
The scope is deliberately narrower than every study that mentions ketamine: ordinary anesthesia and pain-control trials are excluded. 18 active records closed to enrollment and 1 suspended record appear separately below.
Start with the question—not the drug’s reputation.
Every “official record” link opens ClinicalTrials.gov. These filters narrow records to read. They do not screen your diagnosis, medicines, health history, exclusions or the local site’s actual capacity.
40 records shown
Age stays in this browser tab. It is not sent or saved. A matching posted range is not a finding that you qualify. When you choose a region, other listed locations are hidden; each visible location keeps its own posted status—or says when none was posted.
Pragmatic Trial of Psilocybin Therapy in Palliative Care
- Question
- Demoralization in palliative care
- Stage
- Phase 2
- Posted age range
- 18+ years
- Purpose
- Treatment or care-model study
- Record verified
- 2025-11
- Update posted
- Nov 25, 2025
The study compares psilocybin and ketamine. It is not a general depression trial.
Mindfulness-Assisted Psychedelic Therapy
- Question
- Mental health
- Stage
- Phase 2
- Posted age range
- 25+ years
- Purpose
- Treatment or care-model study
- Record verified
- 2026-08
- Update posted
- Aug 6, 2026
Read the eligibility section closely; the registry condition label is broad.
Study of Psilocybin for Anorexia in Young Adults
- Question
- Anorexia nervosa
- Stage
- Phase 2
- Posted age range
- 18–25 years
- Purpose
- Treatment or care-model study
- Record verified
- 2026-01
- Update posted
- Mar 3, 2026
The registry shows two UCSF entries with different local statuses; verify the recruiting location in the federal record.
Psilocybin Therapy for Depression in Parkinson's Disease
- Question
- Parkinson disease and depression
- Stage
- Phase 2
- Posted age range
- 40–80 years
- Purpose
- Treatment or care-model study
- Record verified
- 2026-05
- Update posted
- Aug 7, 2026
This is for a defined neurological and depression population, not depression generally.
A Study of a Deuterated Psilocin Analog in Major Depressive Disorder
- Question
- Major depressive disorder
- Stage
- Phase 3
- Posted age range
- 18–85 years
- Purpose
- Treatment or care-model study
- Record verified
- 2026-02
- Update posted
- Aug 26, 2026
CYB003 is investigational. Withdrawn California locations are deliberately omitted here.
Psilocybin-Assisted Therapy for Physician Well-Being and Burnout
- Question
- Physician burnout
- Stage
- Phase 1 / Phase 2
- Posted age range
- 21–70 years
- Purpose
- Treatment or care-model study
- Record verified
- 2025-11
- Update posted
- Jul 21, 2026
Eligibility is limited to the population described in the study record.
Psilocybin-Assisted CBT for Depression
- Question
- Major depressive disorder
- Stage
- Phase 1 / Phase 2
- Posted age range
- 21–60 years
- Purpose
- Treatment or care-model study
- Record verified
- 2025-12
- Update posted
- Feb 12, 2026
The study compares cognitive behavioral therapy and minimal supportive therapy around psilocybin.
Study of Psilocybin Under Anesthesia Controlled by EEG
- Question
- Major depression
- Stage
- Phase 2
- Posted age range
- 25–65 years
- Purpose
- Treatment or care-model study
- Record verified
- 2026-04
- Update posted
- May 6, 2026
The registry says not yet recruiting. Do not treat a listed contact as an enrollment promise.
Group Psilocybin-Assisted CBT for Depression
- Question
- Major depressive disorder
- Stage
- Phase 2
- Posted age range
- 21–60 years
- Purpose
- Treatment or care-model study
- Record verified
- 2026-04
- Update posted
- May 4, 2026
The federal record does not yet list a central contact.
Psilocybin Therapy for Methamphetamine Use Disorder and HIV
- Question
- Methamphetamine use disorder and HIV
- Stage
- Phase 2
- Posted age range
- 25–64 years
- Purpose
- Treatment or care-model study
- Record verified
- 2026-08
- Update posted
- Aug 11, 2026
This study is for people who meet both the substance-use and HIV eligibility criteria.
A Phase 3 Trial of DT120 for Major Depressive Disorder
- Question
- Major depressive disorder
- Stage
- Phase 3
- Posted age range
- 18–74 years
- Purpose
- Treatment or care-model study
- Record verified
- 2026-07
- Update posted
- Aug 10, 2026
The study drug is investigational lysergide tartrate. California sites have different statuses.
Tolerability of MDMA in Schizophrenia
- Question
- Schizophrenia
- Stage
- Phase 1 / Phase 2
- Posted age range
- 18–60 years
- Purpose
- Safety or mechanism study
- Record verified
- 2026-07
- Update posted
- Jul 17, 2026
This is an early safety and tolerability study, not approved schizophrenia treatment.
MDMA-Assisted CBT for OCD
- Question
- Obsessive-compulsive disorder
- Stage
- Phase 2
- Posted age range
- 18+ years
- Purpose
- Treatment or care-model study
- Record verified
- 2026-03
- Update posted
- Mar 5, 2026
The protocol also includes methamphetamine as a comparator. Read the arms before volunteering.
MDMA-Assisted Therapy for Veterans With PTSD
- Question
- Moderate to severe PTSD in veterans
- Stage
- Phase 2
- Posted age range
- 18+ years
- Purpose
- Treatment or care-model study
- Record verified
- 2026-08
- Update posted
- Aug 19, 2026
Veteran status and the full eligibility rules matter. Two Los Angeles VA entries have different local statuses.
MDMA-Assisted Cognitive Processing Therapy for Veterans With PTSD
- Question
- Severe PTSD in veterans
- Stage
- Phase 2
- Posted age range
- 18+ years
- Purpose
- Treatment or care-model study
- Record verified
- 2025-07
- Update posted
- Jul 31, 2025
The registry record is older than several others in this snapshot; verify it before acting.
Safety and Efficacy of TSND-201 for PTSD
- Question
- Post-traumatic stress disorder
- Stage
- Phase 3
- Posted age range
- 18+ years
- Purpose
- Treatment or care-model study
- Record verified
- 2026-05
- Update posted
- Jun 12, 2026
Methylone is an investigational entactogen. It is not MDMA and is not approved PTSD care.
Ketamine's Rapid Effects in OCD
- Question
- Obsessive-compulsive disorder
- Stage
- Phase 2
- Posted age range
- 18–65 years
- Purpose
- Treatment or care-model study
- Record verified
- 2026-04
- Update posted
- Apr 24, 2026
The trial examines ketamine with naltrexone or placebo; psychiatric ketamine remains off-label.
Pilot Study of RR-HNK in OCD
- Question
- Obsessive-compulsive disorder
- Stage
- Phase 1 / Phase 2
- Posted age range
- 18–65 years
- Purpose
- Treatment or care-model study
- Record verified
- 2026-08
- Update posted
- Aug 12, 2026
RR-HNK is a ketamine metabolite under study. It is not an approved OCD medication.
Ketamine-Assisted Mindfulness-Oriented Recovery for Opioid Use Disorder
- Question
- Treatment-resistant opioid use disorder
- Stage
- Phase 2
- Posted age range
- 18+ years
- Purpose
- Treatment or care-model study
- Record verified
- 2026-01
- Update posted
- Feb 3, 2026
The registry says not yet recruiting. This does not replace established medications for opioid use disorder.
Psychotherapy With Intranasal Esketamine for Suicidal Ideation
- Question
- Suicidal ideation
- Stage
- Not applicable
- Posted age range
- 18–70 years
- Purpose
- Treatment or care-model study
- Record verified
- 2026-01
- Update posted
- Feb 9, 2026
Invitation-only means participants come from a predetermined population. It is not a public enrollment route or crisis service.
ECT Versus Ketamine Over the Lifespan
- Question
- Acute suicidal depression
- Stage
- Phase 4
- Posted age range
- 18–90 years
- Purpose
- Treatment or care-model study
- Record verified
- 2025-12
- Update posted
- Dec 15, 2025
Invitation-only is not a crisis access path. In immediate danger, use 988, 911, or the nearest emergency department.
Esketamine Nasal Spray Versus Placebo in Treatment-Resistant Depression
- Question
- Treatment-resistant depression
- Stage
- Phase 3
- Posted age range
- 18+ years
- Purpose
- Treatment or care-model study
- Record verified
- 2026-08
- Update posted
- Aug 28, 2026
This is a specific research protocol. It does not describe every FDA-approved use of Spravato.
Neural Effects of Intravenous DMT
- Question
- Healthy participants
- Stage
- Phase 1
- Posted age range
- 18–65 years
- Purpose
- Safety or mechanism study
- Record verified
- 2026-07
- Update posted
- Jul 9, 2026
This study examines neural effects. It is not a mental-health treatment study.
Mapping Ibogaine Neural Dynamics in Opioid Use Disorder
- Question
- Opioid use disorder
- Stage
- Not applicable
- Posted age range
- 21–70 years
- Purpose
- Observational study
- Record verified
- 2026-05
- Update posted
- May 18, 2026
The registered intervention is MRI/EEG observation. The California study does not provide ibogaine treatment.
Effects of Psilocybin on Visual Perception and Brain Representations
- Question
- Visual perception
- Stage
- Phase 1
- Posted age range
- 21+ years
- Purpose
- Safety or mechanism study
- Record verified
- 2026-07
- Update posted
- Jul 10, 2026
This is not a treatment study.
Persisting Effects of Psilocybin on Structural Plasticity in Older Adults
- Question
- Healthy older adults
- Stage
- Phase 1
- Posted age range
- 60–85 years
- Purpose
- Safety or mechanism study
- Record verified
- 2025-10
- Update posted
- Oct 21, 2025
This is not treatment for a diagnosed condition.
Interaction of Psilocybin and the Context of Administration
- Question
- Healthy participants with lower-than-average well-being
- Stage
- Phase 2
- Posted age range
- 21–70 years
- Purpose
- Safety or mechanism study
- Record verified
- 2026-06
- Update posted
- Jun 4, 2026
The study tests context as part of the intervention. It is not ordinary psychotherapy access.
Psilocybin With Intracranial Neural Sensing
- Question
- Chronic pain
- Stage
- Phase 1
- Posted age range
- 21–75 years
- Purpose
- Safety or mechanism study
- Record verified
- 2025-04
- Update posted
- Jun 6, 2025
Invitation-only means this is not a public enrollment or treatment route.
Psychedelics in Healthy Older Adults With Low Well-Being
- Question
- Older adults with low well-being
- Stage
- Phase 1
- Posted age range
- 50–85 years
- Purpose
- Safety or mechanism study
- Record verified
- 2025-12
- Update posted
- Jun 8, 2026
This is not depression treatment and should not be described that way.
Safety and Tolerability of Psilocybin in Healthy Older Adults
- Question
- Healthy adults ages 65–85
- Stage
- Phase 1
- Posted age range
- 65–85 years
- Purpose
- Safety or mechanism study
- Record verified
- 2026-08
- Update posted
- Aug 10, 2026
This is a safety and tolerability study, not a treatment trial.
RE104 for Adjustment Disorder With Cancer or Other Medical Illness
- Question
- Adjustment disorder with cancer or another medical illness
- Stage
- Phase 2
- Posted age range
- 18–80 years
- Purpose
- Treatment or care-model study
- Record verified
- 2026-08
- Update posted
- Aug 24, 2026
RE104 is an investigational psilocin analog. This record is limited to the diagnosis and medical-illness criteria in the protocol.
RE104 for Generalized Anxiety Disorder
- Question
- Generalized anxiety disorder
- Stage
- Phase 2
- Posted age range
- 18–74 years
- Purpose
- Treatment or care-model study
- Record verified
- 2026-05
- Update posted
- Aug 18, 2026
RE104 is investigational. A recruiting site and a study result are not an approved anxiety treatment.
Ketamine Effects on Learning in Eating Disorders
- Question
- Anorexia nervosa or atypical anorexia nervosa
- Stage
- Phase 2
- Posted age range
- 16–26 years
- Purpose
- Safety or mechanism study
- Record verified
- 2025-06
- Update posted
- Jun 12, 2026
The posted age range begins at 16, but enrollment is invitation-only. This is not an adolescent care or referral route.
Human Neural Circuits Electrophysiology During Cognition
- Question
- Neural circuits in people receiving psychiatric care
- Stage
- Phase 1
- Posted age range
- 18+ years
- Purpose
- Safety or mechanism study
- Record verified
- 2026-04
- Update posted
- Apr 22, 2026
The record studies brain signals during cognition. It is not ordinary ketamine treatment or proof that ketamine treats every listed psychiatric condition.
Understanding Ketamine's Dissociative Effects
- Question
- Ketamine dissociation in people with epilepsy
- Stage
- Phase 1
- Posted age range
- 18+ years
- Purpose
- Safety or mechanism study
- Record verified
- 2026-04
- Update posted
- Apr 22, 2026
This study examines dissociation in a defined epilepsy population. It is not a depression-treatment trial.
CYB003 Long-Term Extension Study in Major Depressive Disorder
- Question
- Major depressive disorder
- Stage
- Phase 3
- Posted age range
- 18–85 years
- Purpose
- Treatment or care-model study
- Record verified
- 2026-07
- Update posted
- Jul 13, 2026
This is an extension study for a predetermined participant population, not open enrollment for CYB003 treatment.
Longitudinal Assessment of Depression Treatment Response
- Question
- Depressed mood during standard-care esketamine or TMS
- Stage
- Not applicable
- Posted age range
- 18+ years
- Purpose
- Observational study
- Record verified
- 2026-04
- Update posted
- Apr 14, 2026
The study observes people already prescribed standard-care esketamine, TMS or SAINT. The research record does not assign or provide that treatment.
Speech Markers of Response to Spravato or TMS
- Question
- Depression, PTSD or bipolar disorder during standard care
- Stage
- Not applicable
- Posted age range
- 18–68 years
- Purpose
- Observational study
- Record verified
- 2025-02
- Update posted
- Mar 18, 2025
The study records speech from people already scheduled for Spravato or TMS. It does not assign the treatment, and invitation-only is not a public access route.
Cognitive Training as an Adjunct to Ketamine in Real-World Clinics
- Question
- Depressive disorders during existing ketamine or esketamine care
- Stage
- Not applicable
- Posted age range
- 18–80 years
- Purpose
- Treatment or care-model study
- Record verified
- 2026-08
- Update posted
- Aug 19, 2026
The research intervention is cognitive training. Participants must already be clinically enrolled for ketamine or esketamine care; the Oakland site itself says not yet recruiting.
Ketamine for Depression in Veterans With Parkinson's Disease
- Question
- Depression in veterans with Parkinson's disease
- Stage
- Phase 2
- Posted age range
- 40–80 years
- Purpose
- Treatment or care-model study
- Record verified
- 2026-04
- Update posted
- Apr 13, 2026
The official title names depression, neuroplasticity and inflammation in veterans with Parkinson's disease. It is not a general Parkinson's or depression-care route.
No record matches those filters.
Change one filter, or use the federal registry for a broader search. An empty result here does not prove that no study exists.
The only record here with a posted range below 18 begins at age 16 and enrolls by invitation. It is not a public referral route or a care plan for a child or teenager.
One record is suspended.
Safety profile of psilocybin for cocaine use disorder
The registry says suspended. This is not a current enrollment route; read the federal record for the sponsor-posted reason and any later update.
NCT06102434 official record ↗Active studies that are not recruiting.
These records may still produce results. “Active, not recruiting” means participants are still receiving an intervention or being examined, but new participants are not currently being enrolled.
DT120 for generalized anxiety disorder (Voyage)
Generalized anxiety disorder · La Jolla, San Francisco, Santa Monica
NCT06741228 official record ↗LSD / lysergide · Phase 3MM120 for generalized anxiety disorder (Panorama)
Generalized anxiety disorder · Los Angeles
NCT06809595 official record ↗LSD / lysergide · Phase 3DT120 for major depressive disorder (Emerge)
Major depressive disorder · La Jolla, Santa Monica
NCT06941844 official record ↗MDMA · Phase 3MDMA-assisted massed prolonged exposure for PTSD
Post-traumatic stress disorder · San Diego
NCT06117306 official record ↗Ibogaine · ObservationalIbogaine-magnesium in veterans with repeated blast exposure
Blast or combat exposure and head injury · Stanford
NCT04313712 official record ↗Ibogaine + 5-MeO-DMT · ObservationalTrifecta Research Study
PTSD, brain injury, depression and suicidal ideation · Northridge
NCT07717866 official record ↗Psilocybin · Phase 3Psilocybin for major depressive disorder
Major depressive disorder · La Jolla, Los Angeles, Santa Monica
NCT06308653 official record ↗Psilocybin · Phase 2Psilocybin in treatment-resistant depression
Treatment-resistant depression · Palo Alto
NCT04433858 official record ↗Psilocybin · Phase 1 / Phase 2Psilocybin therapy for chronic low back pain
Chronic low-back pain · San Francisco
NCT05351541 official record ↗Ketamine · Phase 2Ketamine for methamphetamine use disorder
Methamphetamine use disorder · San Leandro
NCT06496750 official record ↗Psilocybin · Phase 2COMP360 in recurrent major depressive disorder
Recurrent major depressive disorder · La Jolla
NCT05733546 official record ↗Psilocybin · Phase 2Set and setting in psilocybin-assisted therapy for alcohol use disorder
Alcohol use disorder · Santa Monica
NCT04410913 official record ↗Psilocin / psilocybin · Phase 1Comparing psilocin and psilocybin in healthy adults
Healthy participants · San Francisco
NCT05317689 official record ↗Psilocybin · Phase 1Neural and physiological correlates of psychedelic sub-states
Healthy participants · San Francisco
NCT05698511 official record ↗Ketamine · Phase 4Ketamine during sedation for chronic pain and depression
Chronic pain and depression · Stanford
NCT06317636 official record ↗Psilocybin · Phase 2Psilocybin therapy for depression in bipolar II disorder
Bipolar II depression · San Francisco
NCT05065294 official record ↗CYB003 (psilocin analog) · Phase 3CYB003 in major depressive disorder
Major depressive disorder · Bellflower, La Jolla, Los Angeles, Montclair, Oceanside, San Francisco, San Juan Capistrano
NCT06564818 official record ↗Psilocybin (COMP360) · Phase 3Two administrations of COMP360 in treatment-resistant depression
Treatment-resistant depression · Bellflower, Encino, La Jolla, Los Angeles, Montclair, Oakland, Orange, Riverside, San Jose, Santa Ana, Stanford, Thousand Oaks, Upland
NCT05711940 official record ↗No California treatment route appeared in this snapshot.
Ayahuasca
No recruiting or not-yet-recruiting California treatment study appeared in the intervention search used for this snapshot.
Mescaline
No recruiting or not-yet-recruiting California treatment study appeared in the intervention search used for this snapshot.
5-MeO-DMT
One California observational combination record was active but not recruiting; no recruiting California treatment study appeared in this snapshot.
This is a result of a dated registry search, not proof that research does not exist elsewhere or that the result will remain zero. Ayahuasca, mescaline and 5-MeO-DMT are not FDA-approved mental-health treatments, and this dated official-source review identified no statewide California licensed-treatment system for them.
Ask the questions the headline leaves out.
- Which part of the eligibility rules fits me?A diagnosis alone rarely qualifies someone.
- Is the California site itself recruiting?The overall study and the local site can have different statuses.
- What could I receive?Ask about placebo, comparator, dose, randomization and masking.
- What must I stop or change first?Do not change medication from a webpage; ask the study and your own prescriber.
- How many visits and how much travel?Screening, dosing and follow-up may happen on different days.
- What costs, payment or compensation apply?A study can cover research procedures without covering ordinary medical care.
- Who handles a medical or psychiatric emergency?Get the onsite and after-hours plan before consent.
- Who pays if research causes an injury?Read the consent form; do not accept a verbal summary.
Do not wait for a study to become treatment.
Depression, PTSD, OCD and substance-use disorders already have established care routes. A trial can be a research choice for someone who qualifies; it is not the price of receiving help now.
The registry record is the source of status—not the study advertisement.
- ClinicalTrials.gov, API v2 and each linked NCT study record. 40 open, coming or invitation-only records, 18 active records closed to enrollment, and 1 suspended record were queried and human-checked August 28, 2026.
- ClinicalTrials.gov, protocol registration definitions: recruiting, not yet recruiting, enrolling by invitation, and active not recruiting.
- ClinicalTrials.gov, How to Read a Study Record: sponsor-entered status, study contacts, locations, eligibility and update dates.
- U.S. Food and Drug Administration, Psychedelic Drugs: Considerations for Clinical Investigations, final guidance, July 2026.
- U.S. Food and Drug Administration, Development and Approval Process: research stages and what FDA approval means.
- U.S. Food and Drug Administration, access to investigational drugs: clinical trials and expanded-access routes are distinct.
- Drug Enforcement Administration, Hallucinogens Drug Fact Sheet, 2024 edition: federal controlled-substance status and risks.
- Governor of California, SB 58 veto message, October 7, 2023: the statewide decriminalization proposal did not become law.
Educational information, not medical advice, legal advice, research recruitment, a recommendation to enroll, or a claim that a study will accept you. Registry and posted eligibility ranges checked August 28, 2026. A weekly automated watch checks every curated record and unions two high-recall ClinicalTrials.gov searches; new or changed records open an editorial review item and never publish themselves. Next full human review is due November 26, 2026. Licensed-prescriber and California legal review pending. Paid for by participating therapists. Inclusion is computed, never purchased. No ads. No data sold.